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5 January 2026 · 57 min

AI CAN’T SOLVE AGING… Unless You Do THIS First - Carina Kern

With Carina Kern · Hosted by Julian Issa

What if aging is not an inevitable decline but a solvable systems problem hiding in plain sight?

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AI CAN’T SOLVE AGING… Unless You Do THIS First - Carina Kern
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What if aging is not an inevitable decline but a solvable systems problem hiding in plain sight?

Julian sits down with Carina Kern, a scientist working at the intersection of longevity research and medicine, for a wide ranging conversation on how aging actually works inside the body. Together, they explore why traditional medicine has struggled to address age-related decline and why treating one disease or one organ at a time may be missing the bigger picture. Carina introduces a systems level way of thinking about aging, explaining how cellular damage spreads across the body and why identifying key biological nodes could change how we prevent degeneration altogether.

Julian and Carina also dive into Carina’s research on necrosis, a form of uncontrolled cell death that may sit at the core of aging and many chronic diseases. Carina explains how her team is developing a first in class anti necrotic therapy, how artificial intelligence is being used to uncover system wide interventions, and why the kidney has become a powerful model for studying accelerated aging. The conversation expands beyond Earth as well, touching on what space travel reveals about rapid aging and why protecting human biology may be essential for the future of human exploration.

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